Home >Synthetic Flavours > 4'-Chloroacetoacetanilide
- Chemical Name: 4'-Chloroacetoacetanilide
- CAS No.: 101-92-8
Cost-effective and customizable 4'-Chloroacetoacetanilide 101-92-8 in stock
- Molecular Formula: C10H10ClNO2
- Molecular Weight: 211.648
- Appearance/Colour: off-white to beige crystalline powder
- Melting Point: 131-134 °C(lit.)
- Refractive Index: 1.5388 (estimate)
- Boiling Point: 400.5 °C at 760 mmHg
- PKA: 11.00±0.46(Predicted)
- Flash Point: 196 °C
- PSA： 46.17000
- Density: 1.285 g/cm3
- LogP: 2.33060
101-92-8 Relevant articles
Design, Multicomponent Synthesis and Characterization of Diversely Substituted Pyrazolo[1,5-a] Pyrimidine Derivatives
Ghelani, Satish M.,Naliapara, Yogesh T.
, p. 1843 - 1851 (2016)
The synthesis of various heterocyclic co...
Antiproliferative effect, alteration of cancer cell cycle progression and potential MET kinase inhibition induced by 3,4-dihydropyrimidin-2(1H)-one C5 amide derivatives
Moosavi, Fatemeh,Ebadi, Ahmad,Mohabbati, Maryam,Damghani, Tahereh,Mortazavi, Motahareh,Miri, Ramin,Firuzi, Omidreza
, (2021)
Cancer continues to be the second leadin...
Synthesis of β-Ketoamide Curcumin Analogs for Anti-Diabetic and AGEs Inhibitory Activities
Banuppriya, Govindharasu,Sribalan, Rajendran,Fathima, Sulthan Alavudeen Rizwan,Padmini, Vediappen
, (2018)
Two different series of novel β-ketoamid...
Ru(bpy)33+ electrochemiluminescence detection of aliphatic and aromatic amines with diketene
Uchikura, Kazuo
, p. 98 - 99 (2003)
A new derivatization method for the dete...
Nickel-promoted oxidative domino Csp3-H/N-H bond double-isocyanide insertion reaction to construct pyrrolin-2-ones
Wen, Li-Rong,Wang, Ning-Ning,Du, Wu-Bo,Ma, Qiang,Zhang, Lin-Bao,Li, Ming
, p. 2895 - 2900 (2021)
The first nickel-catalyzed oxidative dom...
Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones
Daniliuc, Constantin,Glorius, Frank,Hu, Tianjiao,Lückemeier, Lukas
supporting information, p. 23193 - 23196 (2021/09/25)
Direct enantioselective hydrogenation of...
Synthesis and in vitro Antidiabetic Screening of Novel Dihydropyrimidine Derivatives
Lalpara,Vachhani,Hadiyal,Goswami,Dubal
, p. 241 - 246 (2021/04/02)
Abstract: A series of N-substituted-6-me...
Compound containing thiophene structure and application thereof in medicine
-
Paragraph 0126-0131, (2021/10/30)
The present invention provides a compoun...
101-92-8 Process route
-
-
106-47-8
4-chloro-aniline
-
-
105-45-3
acetoacetic acid methyl ester
-
-
101-92-8
4'-Chloroacetoacetanilide
| Conditions | Yield |
|---|---|
|
With
pyridine; dmap;
In
5,5-dimethyl-1,3-cyclohexadiene;
for 8h;
Reflux;
|
80%
|
|
With
1,1,1,3',3',3'-hexafluoro-propanol;
In
acetonitrile;
at 80 ℃;
for 12h;
Sealed tube;
Green chemistry;
|
75%
|
|
In
toluene;
for 24h;
Reflux;
|
-
-
1118-84-9
allyl acetoacetate
-
-
106-47-8
4-chloro-aniline
-
-
101-92-8
4'-Chloroacetoacetanilide
| Conditions | Yield |
|---|---|
|
With
1,1,1,3',3',3'-hexafluoro-propanol;
In
acetonitrile;
at 80 ℃;
for 12h;
Sealed tube;
Green chemistry;
|
73%
|
101-92-8 Upstream products
-
110-86-1
pyridine
-
56-23-5
tetrachloromethane
-
141-97-9
ethyl acetoacetate
-
106-47-8
4-chloro-aniline
101-92-8 Downstream products
-
2585-04-8
6-chloro-4-methyl-quinolin-2-ol
-
34797-69-8
p-chloro-o-nitroacetoacetanilide
-
64596-12-9
3-amino-crotonic acid-(4-chloro-anilide)
-
42248-27-1
2-(hydroxyimino)-3-oxo-N-(4-chlorophenyl)butanamide