![4-Chloro-1-[4-(1-methylethyl)phenyl]-1-butanone](/upload/2026/5/4748accd00014242bb4840dc3f3554d0_512995.png)
- Chemical Name: 4-Chloro-1-[4-(1-methylethyl)phenyl]-1-butanone
- CAS No.: 70289-38-2
Buy high quality and low price 4-Chloro-1-[4-(1-methylethyl)phenyl]-1-butanone 70289-38-2 now
- Molecular Formula: C13H17 Cl O
- Molecular Weight: 224.73
- Boiling Point: 337.9oC at 760 mmHg
- Flash Point: 194.2oC
- PSA： 17.07000
- Density: 1.043g/cm3
- LogP: 4.01170
70289-38-2 Relevant articles
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from: Mycobacterium tuberculosis to overcome kanamycin resistance
Garneau-Tsodikova, Sylvie,Garzan, Atefeh,Green, Keith D.,Holbrook, Selina Y. L.,Hou, Caixia,Krieger, Kyle,Pang, Allan H.,Parish, Tanya,Posey, James E.,Punetha, Ankita,Thamban Chandrika, Nishad,Tsodikov, Oleg V.,Willby, Melisa J.
supporting information, p. 1894 - 1909 (2022/01/12)
Tuberculosis (TB), caused by Mycobacteri...
A fexofenadine and method for synthesizing intermediate
-
Paragraph 0047; 0048, (2018/04/26)
The invention relates to a simple and ef...
The synthesis of ω-(2-aryl-1,3-dioxolan-2-yl)alkyl purine derivatives and their activity towards HIV reverse transcriptase
Komissarov,Valuev-Elliston,Ivanova,Kochetkov,Kritzyn
, p. 37 - 45 (2015/02/05)
Novel derivatives of 6-substituted purin...
Novel and efficient method for the synthesis of racemic fexofenadine
Raghavendra,Harsha,Vinaya,Mantelingu,Rangappa
experimental part, p. 2296 - 2303 (2011/07/30)
Fexofenadine is a selective H1-histamine...
70289-38-2 Process route
-
-
98-82-8
Isopropylbenzene
-
-
4635-59-0
4-Chlorobutanoyl chloride
-
-
70289-38-2
4-Chloro-1-(4-isopropyl-phenyl)-butan-1-one
| Conditions | Yield |
|---|---|
|
4-Chlorobutanoyl chloride;
With
aluminum (III) chloride;
In
dichloromethane;
at 0 - 5 ℃;
for 0.5h;
Isopropylbenzene;
In
dichloromethane;
at 5 - 10 ℃;
for 0.5h;
|
94%
|
|
4-Chlorobutanoyl chloride;
With
aluminum (III) chloride;
In
dichloromethane;
at -10 ℃;
Isopropylbenzene;
In
dichloromethane;
at 5 - 20 ℃;
for 10h;
|
92%
|
|
Isopropylbenzene; 4-Chlorobutanoyl chloride;
With
aluminum (III) chloride;
In
dichloromethane;
at 5 - 20 ℃;
for 1.58333 - 1.91667h;
With
water;
In
dichloromethane;
at 0 - 20 ℃;
for 1.5 - 2h;
Product distribution / selectivity;
|
87%
|
|
With
aluminium trichloride;
In
dichloromethane;
at 5 - 20 ℃;
for 14.5h;
|
86%
|
|
aluminum (III) chloride;
In
dichloromethane;
at 5 - 8 ℃;
for 14h;
|
86%
|
|
4-Chlorobutanoyl chloride;
With
aluminum (III) chloride;
In
1,2-dichloro-ethane;
at 0 ℃;
for 0.25h;
Inert atmosphere;
Isopropylbenzene;
In
1,2-dichloro-ethane;
at 20 ℃;
for 12h;
Inert atmosphere;
|
62%
|
|
With
aluminum (III) chloride;
at 0 - 20 ℃;
for 2.08333h;
|
-
-
70289-38-2
4-Chloro-1-(4-isopropyl-phenyl)-butan-1-one
| Conditions | Yield |
|---|---|
|
|
86%
|
|
|
86%
|
|
|
|
|
|
70289-38-2 Upstream products
-
98-82-8
Isopropylbenzene
-
4635-59-0
4-Chlorobutanoyl chloride
70289-38-2 Downstream products
-
112933-72-9
(S)-1-Cyclopropyl-1-(4-isopropyl-phenyl)-2-methanesulfinyl-ethanol
-
123-56-8
Succinimide
-
169280-04-0
1-[4-(1-Bromo-1-methyl-ethyl)-phenyl]-4-chloro-butan-1-one
-
35981-66-9
(4-Bromomethyl-phenyl)-cyclopropyl-methanone